Free Web NovelChapter 1533: Chapter 725: Nobel-Level Achievements_2
It is a medically recognized fact that people with the same immune characteristics do not exist, in other words, everyone’s body will have an immune rejection response to other people’s cells.
This conclusion has already been recognized.
But think about it, it seems that no institution has conducted enough experiments to verify it.
This is also normal.
Generally, contact with other people’s cells is accomplished through blood transfusions or organ transplants; with the same blood type, the immune rejection response to the transfusion is not significant, and even if cases of no immune rejection reaction exist, without detailed testing, it would not be known.
Organ transplants are even less common, and even if subsequent immune rejection reactions are very mild, they are mostly attributed to the effects of drugs or the strong recovery capabilities of the patients.
Additionally, the data mentioned by Zhao Yi indicate that the probability of the same immune characteristics occurring is also very small.
For the same blood type, there are five thousand and forty immune characteristics.
To conduct detailed screening and verification is certainly a massive undertaking.
When the meeting room quieted down a bit, Zhang Wei asked, "How do we go about setting up such a massive screening experiment? We must collaborate with hospitals to get enough blood samples and enough data."
Li Ming shook his head, "Just one hospital is not enough. Because only through blood, we cannot verify this conclusion. We also must collaborate with other medical and experimental institutions."
Others also expressed their opinions.
It’s easy to verify whether there is an immune rejection response, but it’s very difficult to obtain enough sample data to carry out targeted experiments.
It’s a simple yet massive task.
For the same blood type, with five thousand and forty immune characteristics, to find people with the same immune traits, at the very least, thousands of experiments must be conducted. With bad luck, even tens of thousands of experiments might be necessary, and the required samples, materials, and the volume of experimental work are definitely huge.
Zhao Yi nodded, "I will talk to the institute to have other available staff participate in the research as well, and also, I will apply for research funding in hopes of getting more funds."
"This type of research is international in nature, and it cannot all be funded by the laboratory."
"Also, we can publish the findings first—"
The last part of what Zhao Yi said was somewhat abrupt, but his intention was clear. Once the findings are published, there may be other institutions that will carry out the verification.
It doesn’t matter who conducts this kind of verification experiment. If other institutions help with the validation, they would not need to spend the time and effort to do it again.
That was utterly meaningless.
After the meeting was over, everyone in the laboratory talked about the related conclusions; each of them knew what the correct conclusion meant—
It would be a discovery worthy of the Nobel Prize in Medicine.
——
Zhao Yi was very confident in the experimental results, which is why he had the confidence to directly publish the findings, and verification and the like could be conducted slowly.
If other institutions could help with the verification, that would be more than ideal.
At the same time, elucidating the mechanism of human immune detection is very important for the perfection of the mechanisms involved in the human immune process and for the development of future treatments and drugs.
This research, when applied to clinical applications and drug development, has many possible directions to consider.
After deciding to publish the research paper, Zhao Yi went to the genetic laboratory and found the chief researcher, Zhang Ning. Zhang Ning had always been working in the genetic laboratory, and her personally applied research had made significant progress.
Because of the progress in her research, Zhang Ning’s work became even busier.
After Zhao Yi found Zhang Ning, he immediately explained his intentions, "I hope your laboratory can, based on our conclusions, perform an analysis at the genetic level, enriching the connection between the HLA gene system and extracellular proteins."
He then detailed the experimental conclusions.
Zhang Ning had always been working in the genetic laboratory and had not participated in the research of Zhao Yi’s laboratory. She knew that the laboratory was very busy, but she had not anticipated such an important conclusion. "Are you sure, Academician Zhao? Has this conclusion been verified?"
"Not yet, but I’m very sure," Zhao Yi began to talk about some data, indicating he was ready to publish the results.
Zhang Ning nodded as she listened and said seriously, "If your research is correct, it’s absolutely amazing. It’s very important for enriching the association between genes and cells."
"However, this isn’t about me working anymore, but rather giving me the results."
She said it with a bitter smile.
Genetic specialists work on genetic research; naturally, they hope to achieve breakthroughs in genetics.
If Zhao Yi’s conclusion was correct, then one could directly link the HLA gene system with the cell membrane proteins, providing detailed analysis of immune detection from the genetic and molecular levels. Wouldn’t that just be like laying the results right in front of her?
Zhao Yi, on the other hand, didn’t mind and said, "As long as we publish our findings, there will definitely be labs that will conduct research based on them." What he meant was that instead of giving the results to others, it was better to give them to people on their own team, and besides, their research conclusions also needed support from genetic-level research.
The HLA gene system being discussed by the two is the human Major Histocompatibility Complex, the most polymorphic genetic system known to man, which has been located on the short arm of chromosome 6 at 6p21.31.
The HLA system, consisting of a series of closely linked gene loci, makes up the biological "identity card" of the human body.
The medical community believes that the immune active cells of each individual use HLA as a marker to recognize "self" and "non-self," thereby eliminating "non-self" through immune responses to maintain the integrity of the individual.
In other words, the HLA gene system controls the decision-making genes for immune detection protein sequences.
If research conclusions on the HLA gene system could be obtained, it would corroborate the findings on immune detection protein sequences, and even if individuals with the same immune characteristics had not been found yet, the argument would still be very persuasive.
Zhao Yi and Zhang Ning talked about the research issues and also showed concern for Zhang Ning’s personal projects, but he quickly realized he couldn’t contribute much to Zhang Ning’s projects because they were all related to genetics. Though he could somewhat understand the part about perfecting the human gene bank, other aspects were much more complex.
Latter, Zhao Yi simply stopped talking.
After leaving the genetics laboratory, Zhao Yi thought it over and realized he had underestimated science. He had thought he was ’omnipotent,’ that even in areas he had never researched, he would at least know something.
Now he found that science’s scope was infinitely vast. Just medical research alone encompassed a vast amount of knowledge, including neurology, genetics, immunology, and more. Even just the theoretical studies were numerous. In a new domain, he was still like a beginner, seemingly understanding some things, but when it came to the profound aspects, he knew nothing.
"There are specialists in every field!"
"It’s not possible for me to cover all of science by myself—" Zhao Yi said with self-deprecating laughter, suddenly feeling that the decision to establish a genetics laboratory was extraordinarily wise.
He leisurely returned home.
In the evening, during a company video conference, he heard an interesting piece of news.
Professor Bai Jianwu from the Microbiological Technology Laboratory had applied to participate in microbial research work at the Lunar Base and had also passed the initial physical tests.
"Professor Bai?"
"That’s quite impressive indeed!" Zhao Yi said with some admiration.
Although the age cap for working at the Lunar Base is fifty, in reality, it is not easy for people over 45 to pass the physical examinations.
First and foremost, having no chronic diseases and passing the dizziness test eliminates more than sixty percent of people.
Those who have been involved in long-term research rarely have very good health; some common chronic conditions, like hypertension, are quite prevalent.
Younger people are relatively better off, and even if they are somewhat overweight causing slightly high blood pressure, they can bring it down by losing weight.
After the age of 45, curing hypertension becomes very difficult, and more serious cases can lead to heart problems.
Moreover, the dizziness test is particularly challenging for older individuals.
Bai Jianwu being able to pass the physical test is quite remarkable. His research experience is extensive, which indeed makes him well-suited for work on the Moon. freewёbn૦νeɭ.com
Zhao Yi pondered as he looked up at the round moon outside the window and couldn’t help but think of Li Renzhe.
Li Renzhe is up there now, and by his calculations, he should be returning soon, right?
